Cell surface proteins have a wide range of biological functions, including mediation of cell-cell communication and responses to external signals such as the presence of pathogens or chemical messangers. And they are often used as lineage-specific markers, which define phenotypic and functional differences between cell types, and between normal and diseased cells, such as cancer cells. Rapid...

Cell surface proteins have a wide range of biological functions, including mediation of cell-cell communication and responses to external signals such as the presence of pathogens or chemical messangers. And they are often used as lineage-specific markers, which define phenotypic and functional differences between cell types, and between normal and diseased cells, such as cancer cells. Rapid...

Protein kinases operate by transferring a phosphate group from ATP onto serine, threonine, or tyrosine residues on a protein polypeptide substrate, thereby directly influencing its activity and function. Radioactive studies have demonstrated that approximately 30% of proteins in eukaryotic cells undergo post-translational modifications via phosphorylation. This pivotal...